Involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DISP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DISP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DISP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,262,158–11,262,957 | 216.5 kb | Distal (>10kb) Multiome | 805 | |
| chr1:11,272,615–11,274,143 | 206.0 kb | Distal (>10kb) Multiome | 912 | |
| chr1:11,478,503–11,480,383 | 150 bp | At TSS Multiome | 732 | |
| chr1:11,650,273–11,650,925 | 171.5 kb | Distal (>10kb) Multiome | 495 | |
| chr1:11,653,905–11,655,506 | 175.6 kb | Distal (>10kb) Multiome | 476 | |
| chr1:11,663,895–11,664,883 | 185.1 kb | Distal (>10kb) Multiome | 644 | |
| chr1:11,680,428–11,681,928 | 202.1 kb | Distal (>10kb) Multiome | 820 | |
| chr1:11,682,348–11,682,757 | 203.5 kb | Distal (>10kb) Multiome | 94 | |
| chr1:11,690,815–11,692,563 | 212.6 kb | Distal (>10kb) Multiome | 361 | |
| chr1:11,735,752–11,736,686 | 257.0 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the DISP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.