DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for DIRAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIRAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIRAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,424,712–2,426,099 | 296.1 kb | Distal (>10kb) Multiome | 261 | |
| chr19:2,426,254–2,428,729 | 293.6 kb | Distal (>10kb) Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 264.3 kb | Distal (>10kb) Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 259.3 kb | Distal (>10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 258.2 kb | Distal (>10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 246.6 kb | Distal (>10kb) Multiome | 1104 | |
| chr19:2,478,328–2,479,798 | 242.0 kb | Distal (>10kb) Multiome | 488 | |
| chr19:2,489,041–2,489,512 | 232.0 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 180.4 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 141.9 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,598,968–2,599,665 | 122.0 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 118.8 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,702,249–2,703,088 | 18.6 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 214 bp | At TSS Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 18.8 kb | Distal (>10kb) Multiome | 1063 | |
| chr19:2,782,866–2,783,778 | 62.1 kb | Distal (>10kb) Multiome | 998 | |
| chr19:2,784,850–2,785,981 | 64.1 kb | Distal (>10kb) Multiome | 682 | |
| chr19:2,819,641–2,820,625 | 98.5 kb | Distal (>10kb) Multiome | 826 | |
| chr19:2,840,664–2,842,136 | 120.0 kb | Distal (>10kb) Multiome | 903 | |
| chr19:2,900,564–2,901,033 | 179.5 kb | Distal (>10kb) Multiome | 686 | |
| chr19:2,944,631–2,945,468 | 223.7 kb | Distal (>10kb) Multiome | 891 | |
| chr19:2,950,070–2,951,291 | 229.5 kb | Distal (>10kb) Multiome | 962 | |
| chr19:2,976,688–2,977,848 | 256.1 kb | Distal (>10kb) Multiome | 715 | |
| chr19:2,983,511–2,984,586 | 262.7 kb | Distal (>10kb) Multiome | 523 |
Genomic view of the DIRAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.