This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for DIPK1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIPK1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIPK1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,438,826–136,440,227 | 272.7 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 229.2 kb | Distal (>10kb) Multiome | 938 | |
| chr9:136,545,392–136,547,129 | 166.4 kb | Distal (>10kb) Multiome | 710 | |
| chr9:136,572,053–136,572,865 | 140.2 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 124.2 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 85.6 kb | Distal (>10kb) Multiome | 451 | |
| chr9:136,665,223–136,666,507 | 46.7 kb | Distal (>10kb) Multiome | 409 | |
| chr9:136,686,875–136,688,079 | 25.1 kb | Distal (>10kb) Multiome | 610 | |
| chr9:136,711,795–136,713,743 | 167 bp | At TSS Multiome | 459 | |
| chr9:136,727,616–136,729,079 | 15.7 kb | Distal (>10kb) Multiome | 1013 | |
| chr9:136,762,846–136,763,902 | 50.6 kb | Distal (>10kb) Multiome | 271 | |
| chr9:136,788,889–136,789,680 | 76.7 kb | Distal (>10kb) Multiome | 351 | |
| chr9:136,790,433–136,792,285 | 78.5 kb | Distal (>10kb) Multiome | 864 | |
| chr9:136,798,823–136,801,421 | 88.8 kb | Distal (>10kb) Multiome | 874 | |
| chr9:136,807,251–136,808,764 | 95.3 kb | Distal (>10kb) Multiome | 714 | |
| chr9:136,842,325–136,842,872 | 129.9 kb | Distal (>10kb) Multiome | 492 | |
| chr9:136,846,187–136,850,214 | 136.9 kb | Distal (>10kb) Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 153.8 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 173.8 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 232.1 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 237.6 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 266.0 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 279.8 kb | Distal (>10kb) Multiome | 720 |
Genomic view of the DIPK1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.