Transcription factors with Perturb-seq knockdown data for DHX9-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHX9-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHX9-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:182,603,748–182,604,847 | 235.1 kb | Distal (>10kb) Multiome HiCAR | 617 | |
| chr1:182,611,551–182,612,259 | 227.6 kb | Distal (>10kb) Multiome | 222 | |
| chr1:182,614,397–182,617,189 | 224.6 kb | Distal (>10kb) Multiome | 882 | |
| chr1:182,699,357–182,700,582 | 139.5 kb | Distal (>10kb) Multiome | 237 | |
| chr1:182,789,198–182,790,098 | 49.9 kb | Distal (>10kb) Multiome | 771 | |
| chr1:182,806,097–182,806,606 | 33.1 kb | Distal (>10kb) Multiome | 157 | |
| chr1:182,838,565–182,840,149 | 194 bp | At TSS Multiome | 1015 | |
| chr1:182,957,895–182,958,423 | 118.5 kb | Distal (>10kb) Multiome | 75 | |
| chr1:183,022,283–183,024,397 | 183.7 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the DHX9-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.