Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DHX57. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHX57 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHX57, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:38,601,968–38,603,924 | 272.8 kb | Distal (>10kb) Multiome | 1077 | |
| chr2:38,665,660–38,666,774 | 209.8 kb | Distal (>10kb) Multiome | 828 | |
| chr2:38,750,264–38,752,290 | 124.4 kb | Distal (>10kb) Multiome | 1162 | |
| chr2:38,875,424–38,876,417 | 37 bp | At TSS Multiome | 853 | |
| chr2:38,959,495–38,960,974 | 84.6 kb | Distal (>10kb) Multiome | 291 | |
| chr2:39,119,799–39,121,499 | 245.1 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:39,123,822–39,125,066 | 248.5 kb | Distal (>10kb) Multiome | 1035 |
Genomic view of the DHX57 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.