DHPS

deoxyhypusine synthase | MIG13

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

Member of: DE-1

Biological processes 16 terms

cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)deoxyhypusine synthase activity (GO:0034038)deoxyhypusine synthase activity (GO:0034038)deoxyhypusine synthase activity (GO:0034038)identical protein binding (GO:0042802)identical protein binding (GO:0042802)peptidyl-hypusine biosynthetic process (GO:0008612)positive regulation of cell population proliferation (GO:0008284)protein binding (GO:0005515)protein maturation (GO:0051604)spermidine catabolic process (GO:0046203)spermidine metabolic process (GO:0008216)spermidine metabolic process (GO:0008216)translation (GO:0006412)

Expression (TPM)

TFs regulating DHPS 0 TFs

Transcription factors with Perturb-seq knockdown data for DHPS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHPS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DHPS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHPS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,400,090–12,401,657	280.2 kb	Distal (>10kb) Multiome	671
chr19:12,440,217–12,441,483	240.3 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	196.6 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	186.0 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	129.9 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	109.7 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	70.5 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	41.2 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	33.7 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	24.2 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	14.6 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	11.9 kb	Distal (>10kb) Multiome	777
chr19:12,672,121–12,672,300	9.1 kb	Proximal (<10kb)	206
chr19:12,676,416–12,676,669	4.7 kb	Proximal (<10kb)	276
chr19:12,681,003–12,682,117	16 bp	At TSS Multiome	994
chr19:12,696,035–12,696,970	15.2 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	21.8 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	41.0 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	42.7 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	53.3 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	55.7 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	76.4 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	84.9 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	94.0 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	96.5 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	101.3 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	108.6 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	110.1 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	112.3 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	120.5 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	125.1 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	144.4 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	151.2 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	152.5 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	157.0 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	159.4 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	166.3 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	186.2 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	191.9 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	200.1 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	204.0 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	209.6 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	231.9 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	238.0 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	252.4 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	257.0 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	264.5 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	275.8 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	284.0 kb	Distal (>10kb) Multiome	733
chr19:14,564,060–14,565,155	1883.1 kb	Distal (>10kb) Multiome HiCAR	226

Genome Browser

Genomic view of the DHPS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.