This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DGKI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGKI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGKI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:137,585,330–137,586,242 | 261.3 kb | Distal (>10kb) Multiome | 79 | |
| chr7:137,752,833–137,753,611 | 93.8 kb | Distal (>10kb) Multiome | 70 | |
| chr7:137,820,272–137,821,389 | 26.1 kb | Distal (>10kb) Multiome | 228 | |
| chr7:137,839,053–137,839,206 | 7.9 kb | Proximal (<10kb) | 11 | |
| chr7:137,840,324–137,840,709 | 6.4 kb | Proximal (<10kb) | 129 | |
| chr7:137,846,350–137,847,725 | 77 bp | At TSS Multiome | 330 | |
| chr7:137,899,155–137,899,772 | 52.3 kb | Distal (>10kb) Multiome | 497 | |
| chr7:138,001,408–138,002,587 | 155.1 kb | Distal (>10kb) Multiome | 897 | |
| chr7:138,014,239–138,015,349 | 167.7 kb | Distal (>10kb) Multiome | 102 |
Genomic view of the DGKI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.