DGAT1
diacylglycerol O-acyltransferase 1 | ARGP1, DGAT

This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

Biological processes 40 terms
2-acylglycerol O-acyltransferase activity (GO:0003846)O-acyltransferase activity (GO:0008374)acyltransferase activity (GO:0016746)diacylglycerol O-acyltransferase activity (GO:0004144)diacylglycerol O-acyltransferase activity (GO:0004144)diacylglycerol O-acyltransferase activity (GO:0004144)diacylglycerol O-acyltransferase activity (GO:0004144)diacylglycerol metabolic process (GO:0046339)diacylglycerol metabolic process (GO:0046339)diacylglycerol metabolic process (GO:0046339)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)fatty acid homeostasis (GO:0055089)glycerolipid metabolic process (GO:0046486)identical protein binding (GO:0042802)lipid storage (GO:0019915)lipid storage (GO:0019915)lipid transport (GO:0006869)long-chain fatty-acyl-CoA metabolic process (GO:0035336)long-chain fatty-acyl-CoA metabolic process (GO:0035336)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)monoacylglycerol biosynthetic process (GO:0006640)monoacylglycerol biosynthetic process (GO:0006640)plasma membrane (GO:0005886)protein binding (GO:0005515)retinoid metabolic process (GO:0001523)retinol O-fatty-acyltransferase activity (GO:0050252)retinol metabolic process (GO:0042572)specific granule membrane (GO:0035579)triglyceride biosynthetic process (GO:0019432)triglyceride biosynthetic process (GO:0019432)triglyceride biosynthetic process (GO:0019432)triglyceride biosynthetic process (GO:0019432)triglyceride metabolic process (GO:0006641)very-low-density lipoprotein particle assembly (GO:0034379)
Expression (TPM)
DGAT1 — as a Regulated Gene

TFs regulating DGAT1 0 TFs

Transcription factors with Perturb-seq knockdown data for DGAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to DGAT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:144,049,063–144,051,761 276.0 kb Distal (>10kb) Multiome 342
chr8:144,060,259–144,061,087 265.9 kb Distal (>10kb) Multiome 727
chr8:144,078,142–144,079,235 248.0 kb Distal (>10kb) Multiome 912
chr8:144,082,187–144,083,105 244.1 kb Distal (>10kb) Multiome 763
chr8:144,094,454–144,095,491 231.7 kb Distal (>10kb) Multiome 798
chr8:144,103,485–144,105,242 222.3 kb Distal (>10kb) Multiome 1033
chr8:144,108,038–144,108,663 218.3 kb Distal (>10kb) Multiome 137
chr8:144,137,565–144,138,500 188.9 kb Distal (>10kb) Multiome HiCAR 817
chr8:144,146,820–144,149,073 178.7 kb Distal (>10kb) Multiome 790
chr8:144,266,293–144,267,098 60.2 kb Distal (>10kb) Multiome 162
chr8:144,290,981–144,292,410 35.2 kb Distal (>10kb) Multiome HiCAR 716
chr8:144,315,833–144,316,450 10.5 kb Distal (>10kb) Multiome HiCAR 396
chr8:144,325,768–144,327,719 232 bp At TSS Multiome 1016
chr8:144,331,281–144,333,847 5.3 kb Proximal (<10kb) Multiome 406
chr8:144,334,247–144,334,510 7.6 kb Proximal (<10kb) 107
chr8:144,336,102–144,339,119 10.2 kb Distal (>10kb) Multiome 922
chr8:144,353,907–144,355,227 27.9 kb Distal (>10kb) Multiome 280
chr8:144,358,142–144,359,070 31.9 kb Distal (>10kb) Multiome 719
chr8:144,369,349–144,369,916 43.0 kb Distal (>10kb) Multiome 204
chr8:144,372,497–144,372,883 46.0 kb Distal (>10kb) Multiome 160
chr8:144,372,993–144,375,084 47.3 kb Distal (>10kb) Multiome 903
chr8:144,408,968–144,410,189 82.8 kb Distal (>10kb) Multiome 920
chr8:144,427,691–144,429,571 101.9 kb Distal (>10kb) Multiome 1000
chr8:144,443,691–144,445,047 117.7 kb Distal (>10kb) Multiome 743
chr8:144,462,568–144,463,422 136.2 kb Distal (>10kb) Multiome 548
chr8:144,463,885–144,468,178 139.1 kb Distal (>10kb) Multiome 910
chr8:144,471,960–144,474,391 145.9 kb Distal (>10kb) Multiome 482
chr8:144,474,517–144,476,543 149.2 kb Distal (>10kb) Multiome 321
chr8:144,477,277–144,478,749 151.3 kb Distal (>10kb) Multiome 679
chr8:144,478,851–144,479,509 152.6 kb Distal (>10kb) Multiome 392
chr8:144,483,979–144,484,843 157.7 kb Distal (>10kb) Multiome 125
chr8:144,495,748–144,496,431 169.4 kb Distal (>10kb) Multiome 131
chr8:144,500,182–144,501,505 174.3 kb Distal (>10kb) Multiome 484
chr8:144,507,995–144,510,268 182.2 kb Distal (>10kb) Multiome 1067
chr8:144,517,168–144,518,442 191.2 kb Distal (>10kb) Multiome 637
chr8:144,521,935–144,523,450 195.8 kb Distal (>10kb) Multiome 663
chr8:144,524,105–144,525,099 198.0 kb Distal (>10kb) Multiome 264
chr8:144,526,399–144,529,305 200.4 kb Distal (>10kb) Multiome 934
chr8:144,529,455–144,530,630 203.5 kb Distal (>10kb) Multiome 284
chr8:144,580,290–144,581,657 254.1 kb Distal (>10kb) Multiome 271

Genome Browser

Genomic view of the DGAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:144,039,063 – 144,591,657
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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