Enables deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in macromolecule depalmitoylation and proteolysis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DESI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DESI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DESI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:244,353,544–244,354,028 | 299.3 kb | Distal (>10kb) Multiome | 404 | |
| chr1:244,361,460–244,362,746 | 291.1 kb | Distal (>10kb) Multiome | 272 | |
| chr1:244,450,993–244,452,731 | 201.0 kb | Distal (>10kb) Multiome | 958 | |
| chr1:244,461,143–244,461,971 | 191.7 kb | Distal (>10kb) Multiome | 511 | |
| chr1:244,647,945–244,648,122 | 5.0 kb | Proximal (<10kb) | 61 | |
| chr1:244,651,947–244,654,106 | 129 bp | At TSS Multiome | 921 | |
| chr1:244,730,143–244,731,325 | 77.6 kb | Distal (>10kb) Multiome | 295 | |
| chr1:244,815,498–244,816,101 | 162.6 kb | Distal (>10kb) Multiome | 177 | |
| chr1:244,833,808–244,836,513 | 182.3 kb | Distal (>10kb) Multiome HiCAR | 1226 | |
| chr1:244,862,633–244,865,438 | 211.5 kb | Distal (>10kb) Multiome | 1124 |
Genomic view of the DESI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.