Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for DERL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DERL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DERL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:5,191,578–5,192,305 | 294.3 kb | Distal (>10kb) Multiome | 771 | |
| chr17:5,281,614–5,283,116 | 203.9 kb | Distal (>10kb) Multiome | 705 | |
| chr17:5,419,157–5,420,471 | 66.3 kb | Distal (>10kb) Multiome | 891 | |
| chr17:5,438,801–5,439,554 | 47.0 kb | Distal (>10kb) Multiome | 889 | |
| chr17:5,468,372–5,469,379 | 17.2 kb | Distal (>10kb) Multiome | 890 | |
| chr17:5,485,725–5,487,042 | 294 bp | At TSS Multiome | 951 | |
| chr17:5,500,534–5,501,338 | 14.9 kb | Distal (>10kb) Multiome | 489 | |
| chr17:5,711,154–5,711,693 | 225.3 kb | Distal (>10kb) Multiome | 46 | |
| chr17:6,443,586–6,444,814 | 958.1 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the DERL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.