Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell-cell adhesion mediated by cadherin. Located in recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:57,543,921–57,544,886 | 148.7 kb | Distal (>10kb) Multiome | 280 | |
| chr3:57,546,064–57,547,149 | 146.3 kb | Distal (>10kb) Multiome | 113 | |
| chr3:57,555,739–57,556,867 | 136.9 kb | Distal (>10kb) Multiome | 1030 | |
| chr3:57,596,484–57,598,208 | 95.5 kb | Distal (>10kb) Multiome | 936 | |
| chr3:57,692,365–57,693,415 | 153 bp | At TSS Multiome | 923 | |
| chr3:57,727,873–57,728,338 | 35.0 kb | Distal (>10kb) Multiome | 20 | |
| chr3:57,755,657–57,757,330 | 63.1 kb | Distal (>10kb) Multiome | 930 | |
| chr3:57,969,842–57,970,308 | 277.0 kb | Distal (>10kb) Multiome | 332 | |
| chr3:57,992,220–57,993,259 | 299.6 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the DENND6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.