Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in endosome to lysosome transport; protein catabolic process; and regulation of Rab protein signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:141,000,143–141,002,200 | 127.2 kb | Distal (>10kb) Multiome | 899 | |
| chr8:141,016,712–141,017,668 | 111.5 kb | Distal (>10kb) Multiome | 80 | |
| chr8:141,026,596–141,027,291 | 101.6 kb | Distal (>10kb) Multiome | 443 | |
| chr8:141,075,037–141,076,064 | 53.0 kb | Distal (>10kb) Multiome | 517 | |
| chr8:141,084,176–141,084,832 | 44.1 kb | Distal (>10kb) Multiome | 417 | |
| chr8:141,127,643–141,129,710 | 153 bp | At TSS Multiome | 851 | |
| chr8:141,305,657–141,306,470 | 177.4 kb | Distal (>10kb) Multiome | 142 | |
| chr8:141,306,734–141,309,264 | 179.9 kb | Distal (>10kb) Multiome | 525 | |
| chr8:141,346,632–141,347,366 | 218.5 kb | Distal (>10kb) Multiome | 369 | |
| chr8:141,351,532–141,352,458 | 223.4 kb | Distal (>10kb) Multiome | 211 | |
| chr8:141,391,326–141,392,706 | 263.4 kb | Distal (>10kb) Multiome | 629 | |
| chr8:141,414,715–141,415,638 | 286.4 kb | Distal (>10kb) Multiome | 339 | |
| chr8:141,417,342–141,418,294 | 289.2 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the DENND3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.