Enables guanyl-nucleotide exchange factor activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:114,510,080–114,511,643 | 158.9 kb | Distal (>10kb) Multiome | 977 | |
| chr1:114,581,305–114,582,040 | 88.3 kb | Distal (>10kb) Multiome | 796 | |
| chr1:114,642,026–114,643,180 | 27.5 kb | Distal (>10kb) Multiome | 125 | |
| chr1:114,666,127–114,666,730 | 3.3 kb | Proximal (<10kb) | 22 | |
| chr1:114,669,579–114,670,824 | 56 bp | At TSS Multiome | 605 | |
| chr1:114,716,313–114,717,190 | 46.8 kb | Distal (>10kb) Multiome | 869 | |
| chr1:114,756,971–114,758,310 | 87.8 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:114,780,205–114,780,915 | 110.6 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the DENND2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.