The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DELEC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DELEC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DELEC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:115,028,151–115,029,125 | 181.2 kb | Distal (>10kb) Multiome HiCAR | 77 | |
| chr9:115,117,919–115,119,196 | 91.3 kb | Distal (>10kb) Multiome | 482 | |
| chr9:115,206,973–115,207,362 | 2.6 kb | Proximal (<10kb) | 81 | |
| chr9:115,395,348–115,396,016 | 185.6 kb | Distal (>10kb) Multiome HiCAR | 63 | |
| chr9:115,494,943–115,495,875 | 285.5 kb | Distal (>10kb) Multiome HiCAR | 383 |
Genomic view of the DELEC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.