Enables 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in fatty acid beta-oxidation. Located in cytosol; mitochondrion; and nucleoplasm. Part of catalytic complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DECR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DECR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DECR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:89,735,590–89,737,765 | 265.4 kb | Distal (>10kb) Multiome | 299 | |
| chr8:89,757,049–89,758,721 | 243.8 kb | Distal (>10kb) Multiome | 975 | |
| chr8:89,901,706–89,903,339 | 99.0 kb | Distal (>10kb) Multiome | 906 | |
| chr8:89,983,654–89,985,025 | 17.0 kb | Distal (>10kb) Multiome | 1128 | |
| chr8:89,992,539–89,993,861 | 8.5 kb | Proximal (<10kb) Multiome | 132 | |
| chr8:89,995,320–89,996,061 | 5.4 kb | Proximal (<10kb) | 189 | |
| chr8:90,000,653–90,002,462 | 145 bp | At TSS Multiome | 917 | |
| chr8:90,006,359–90,006,707 | 4.9 kb | Proximal (<10kb) | 15 | |
| chr8:90,081,366–90,083,237 | 81.4 kb | Distal (>10kb) Multiome | 562 | |
| chr8:90,203,329–90,204,017 | 202.2 kb | Distal (>10kb) Multiome | 129 | |
| chr8:90,644,726–90,647,850 | 644.7 kb | Distal (>10kb) Multiome HiCAR | 987 | |
| chr8:90,984,601–90,986,072 | 983.9 kb | Distal (>10kb) Multiome HiCAR | 606 |
Genomic view of the DECR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.