The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for DDRGK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDRGK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDRGK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:3,045,415–3,046,996 | 158.7 kb | Distal (>10kb) Multiome | 999 | |
| chr20:3,071,569–3,072,466 | 132.5 kb | Distal (>10kb) Multiome | 214 | |
| chr20:3,092,619–3,093,442 | 111.6 kb | Distal (>10kb) Multiome | 180 | |
| chr20:3,159,566–3,160,153 | 44.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr20:3,168,012–3,168,864 | 36.3 kb | Distal (>10kb) Multiome | 598 | |
| chr20:3,172,885–3,174,573 | 31.1 kb | Distal (>10kb) Multiome | 1012 | |
| chr20:3,203,485–3,204,801 | 147 bp | At TSS Multiome | 952 | |
| chr20:3,209,168–3,209,760 | 4.5 kb | Proximal (<10kb) | 782 | |
| chr20:3,218,394–3,218,992 | 14.0 kb | Distal (>10kb) Multiome | 638 | |
| chr20:3,238,062–3,240,422 | 34.8 kb | Distal (>10kb) Multiome | 714 | |
| chr20:3,407,081–3,408,415 | 203.1 kb | Distal (>10kb) Multiome | 825 | |
| chr20:3,408,525–3,409,169 | 204.3 kb | Distal (>10kb) Multiome | 453 | |
| chr20:3,470,330–3,471,668 | 266.3 kb | Distal (>10kb) Multiome | 975 |
Genomic view of the DDRGK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.