This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for DDB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,917,991–46,919,090 | 295.9 kb | Distal (>10kb) Multiome | 405 | |
| chr11:46,936,572–46,937,187 | 277.7 kb | Distal (>10kb) Multiome | 744 | |
| chr11:46,947,422–46,947,958 | 266.6 kb | Distal (>10kb) Multiome | 150 | |
| chr11:47,160,949–47,161,864 | 53.0 kb | Distal (>10kb) Multiome | 322 | |
| chr11:47,176,472–47,177,856 | 37.4 kb | Distal (>10kb) Multiome | 857 | |
| chr11:47,184,866–47,187,095 | 28.0 kb | Distal (>10kb) Multiome | 849 | |
| chr11:47,214,114–47,215,529 | 392 bp | At TSS Multiome | 785 | |
| chr11:47,248,482–47,249,399 | 34.5 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:47,257,299–47,258,204 | 43.4 kb | Distal (>10kb) Multiome | 519 | |
| chr11:47,259,310–47,259,960 | 45.2 kb | Distal (>10kb) Multiome | 270 | |
| chr11:47,268,988–47,270,613 | 55.4 kb | Distal (>10kb) Multiome | 884 | |
| chr11:47,354,896–47,355,720 | 140.9 kb | Distal (>10kb) Multiome | 670 | |
| chr11:47,399,791–47,400,763 | 185.8 kb | Distal (>10kb) Multiome | 450 | |
| chr11:47,407,671–47,409,059 | 193.9 kb | Distal (>10kb) Multiome | 986 | |
| chr11:47,425,998–47,427,263 | 212.1 kb | Distal (>10kb) Multiome | 879 | |
| chr11:47,508,005–47,509,036 | 294.1 kb | Distal (>10kb) Multiome | 73 |
Genomic view of the DDB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.