DDAH2

DDAH family member 2, ADMA-independent | DDAHII, G6A

This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]

Member of: DE-1 Developmental clusters: GC6 GC6

Biological processes 12 terms

cytoplasm (GO:0005737)dimethylargininase activity (GO:0016403)dimethylargininase activity (GO:0016403)dimethylargininase activity (GO:0016403)dimethylargininase activity (GO:0016403)extracellular exosome (GO:0070062)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of apoptotic process (GO:0043066)positive regulation of nitric oxide biosynthetic process (GO:0045429)protein binding (GO:0005515)

Expression (TPM)

TFs regulating DDAH2 0 TFs

Transcription factors with Perturb-seq knockdown data for DDAH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDAH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DDAH2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDAH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:31,441,682–31,442,105	288.5 kb	Distal (>10kb) Multiome	316
chr6:31,462,703–31,463,323	267.2 kb	Distal (>10kb) Multiome	352
chr6:31,497,638–31,498,615	232.2 kb	Distal (>10kb) Multiome	613
chr6:31,541,205–31,542,816	188.2 kb	Distal (>10kb) Multiome	1073
chr6:31,546,485–31,547,136	183.5 kb	Distal (>10kb) Multiome	589
chr6:31,547,301–31,547,742	182.6 kb	Distal (>10kb) Multiome	762
chr6:31,580,713–31,581,330	149.2 kb	Distal (>10kb) Multiome	745
chr6:31,619,744–31,621,435	109.7 kb	Distal (>10kb) Multiome	1127
chr6:31,651,682–31,653,297	77.6 kb	Distal (>10kb) Multiome	1113
chr6:31,660,325–31,660,941	69.5 kb	Distal (>10kb) Multiome	892
chr6:31,664,725–31,666,373	65.4 kb	Distal (>10kb) Multiome	1039
chr6:31,682,887–31,683,880	46.9 kb	Distal (>10kb) Multiome HiCAR	248
chr6:31,702,816–31,703,520	27.0 kb	Distal (>10kb) Multiome	875
chr6:31,713,576–31,714,641	16.1 kb	Distal (>10kb) Multiome	171
chr6:31,728,852–31,730,814	16 bp	At TSS Multiome	979
chr6:31,734,710–31,735,156	4.4 kb	Proximal (<10kb)	570
chr6:31,736,263–31,736,697	6.0 kb	Proximal (<10kb)	727
chr6:31,738,486–31,738,918	8.2 kb	Proximal (<10kb)	609
chr6:31,739,236–31,740,741	9.6 kb	Proximal (<10kb) Multiome	1043
chr6:31,766,045–31,766,778	36.2 kb	Distal (>10kb) Multiome	351
chr6:31,795,097–31,796,366	65.7 kb	Distal (>10kb) Multiome	979
chr6:31,806,162–31,807,183	76.7 kb	Distal (>10kb) Multiome	947
chr6:31,814,125–31,815,936	84.3 kb	Distal (>10kb) Multiome	822
chr6:31,818,020–31,818,663	88.1 kb	Distal (>10kb) Multiome	280
chr6:31,821,306–31,822,544	91.8 kb	Distal (>10kb) Multiome	714
chr6:31,826,770–31,828,135	97.3 kb	Distal (>10kb) Multiome	1000
chr6:31,834,277–31,835,371	104.5 kb	Distal (>10kb) Multiome	1085
chr6:31,862,148–31,864,173	132.7 kb	Distal (>10kb) Multiome	1118
chr6:31,896,965–31,898,037	167.3 kb	Distal (>10kb) Multiome	654
chr6:31,901,114–31,902,643	172.0 kb	Distal (>10kb) Multiome	826
chr6:31,958,527–31,959,598	228.8 kb	Distal (>10kb) Multiome	953
chr6:31,971,421–31,972,872	242.0 kb	Distal (>10kb) Multiome	1059

Genome Browser

Genomic view of the DDAH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.