This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DDAH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDAH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDAH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:85,200,160–85,202,231 | 263.4 kb | Distal (>10kb) Multiome | 895 | |
| chr1:85,224,822–85,225,910 | 239.9 kb | Distal (>10kb) Multiome | 499 | |
| chr1:85,258,924–85,260,262 | 205.5 kb | Distal (>10kb) Multiome | 782 | |
| chr1:85,275,751–85,277,437 | 188.5 kb | Distal (>10kb) Multiome | 868 | |
| chr1:85,307,937–85,308,862 | 156.9 kb | Distal (>10kb) Multiome | 554 | |
| chr1:85,464,074–85,465,652 | 91 bp | At TSS Multiome | 747 | |
| chr1:85,576,283–85,578,303 | 111.9 kb | Distal (>10kb) Multiome | 711 | |
| chr1:85,579,630–85,582,885 | 115.6 kb | Distal (>10kb) Multiome | 929 | |
| chr1:85,707,592–85,709,003 | 243.2 kb | Distal (>10kb) Multiome | 872 |
Genomic view of the DDAH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.