The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for DCTPP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCTPP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCTPP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,182,759–30,183,865 | 246.6 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 94.6 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 74.6 kb | Distal (>10kb) Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 59.2 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 51.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 34.8 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 29.4 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 22.5 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 11.9 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 212 bp | At TSS Multiome | 1060 | |
| chr16:30,437,340–30,437,978 | 7.3 kb | Proximal (<10kb) | 329 | |
| chr16:30,445,340–30,446,062 | 15.8 kb | Distal (>10kb) Multiome | 898 | |
| chr16:30,526,068–30,527,896 | 97.4 kb | Distal (>10kb) Multiome | 1004 | |
| chr16:30,534,370–30,535,460 | 104.9 kb | Distal (>10kb) Multiome HiCAR | 957 | |
| chr16:30,557,913–30,558,847 | 128.5 kb | Distal (>10kb) Multiome HiCAR | 1025 | |
| chr16:30,571,001–30,572,505 | 142.0 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,585,243–30,586,223 | 155.8 kb | Distal (>10kb) Multiome HiCAR | 588 | |
| chr16:30,609,586–30,610,748 | 180.5 kb | Distal (>10kb) Multiome HiCAR | 1030 | |
| chr16:30,634,070–30,634,986 | 204.4 kb | Distal (>10kb) Multiome HiCAR | 907 | |
| chr16:30,650,029–30,651,831 | 220.7 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr16:30,657,638–30,659,894 | 228.3 kb | Distal (>10kb) Multiome HiCAR | 1053 | |
| chr16:30,677,814–30,678,622 | 248.2 kb | Distal (>10kb) Multiome | 177 | |
| chr16:30,697,755–30,699,614 | 269.1 kb | Distal (>10kb) Multiome | 1153 |
Genomic view of the DCTPP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.