The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for DCP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:112,707,010–112,708,233 | 269.3 kb | Distal (>10kb) Multiome | 823 | |
| chr5:112,710,793–112,712,214 | 265.4 kb | Distal (>10kb) Multiome | 154 | |
| chr5:112,737,494–112,738,559 | 239.0 kb | Distal (>10kb) Multiome | 697 | |
| chr5:112,848,068–112,848,715 | 128.3 kb | Distal (>10kb) Multiome | 275 | |
| chr5:112,860,721–112,861,653 | 115.5 kb | Distal (>10kb) Multiome | 948 | |
| chr5:112,920,841–112,922,670 | 55.5 kb | Distal (>10kb) Multiome | 913 | |
| chr5:112,969,306–112,969,549 | 7.2 kb | Proximal (<10kb) | 241 | |
| chr5:112,976,029–112,977,339 | 122 bp | At TSS Multiome | 889 | |
| chr5:113,203,000–113,203,846 | 226.6 kb | Distal (>10kb) Multiome | 546 | |
| chr5:113,268,808–113,270,132 | 292.6 kb | Distal (>10kb) Multiome | 232 |
Genomic view of the DCP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.