Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for DCP1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCP1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCP1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:53,072,497–53,073,757 | 274.6 kb | Distal (>10kb) Multiome | 597 | |
| chr3:53,130,008–53,130,811 | 217.1 kb | Distal (>10kb) Multiome | 781 | |
| chr3:53,160,572–53,162,503 | 186.5 kb | Distal (>10kb) Multiome | 627 | |
| chr3:53,216,604–53,217,511 | 130.6 kb | Distal (>10kb) Multiome | 92 | |
| chr3:53,219,753–53,220,316 | 127.5 kb | Distal (>10kb) Multiome | 367 | |
| chr3:53,254,585–53,256,437 | 91.5 kb | Distal (>10kb) Multiome | 773 | |
| chr3:53,269,991–53,270,526 | 77.3 kb | Distal (>10kb) Multiome | 744 | |
| chr3:53,347,016–53,348,084 | 95 bp | At TSS Multiome | 1111 | |
| chr3:53,493,749–53,494,796 | 146.8 kb | Distal (>10kb) Multiome | 362 | |
| chr3:53,566,580–53,567,182 | 219.4 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the DCP1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.