This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for DCAF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,445,554–63,447,581 | 104.3 kb | Distal (>10kb) Multiome | 896 | |
| chr17:63,476,359–63,478,095 | 73.2 kb | Distal (>10kb) Multiome | 520 | |
| chr17:63,478,783–63,479,370 | 71.4 kb | Distal (>10kb) Multiome | 419 | |
| chr17:63,522,589–63,523,803 | 27.3 kb | Distal (>10kb) Multiome | 705 | |
| chr17:63,549,660–63,551,443 | 170 bp | At TSS Multiome | 1037 | |
| chr17:63,600,715–63,601,423 | 50.4 kb | Distal (>10kb) Multiome | 1122 | |
| chr17:63,621,512–63,623,359 | 71.5 kb | Distal (>10kb) Multiome | 956 | |
| chr17:63,698,705–63,701,428 | 149.7 kb | Distal (>10kb) Multiome | 663 | |
| chr17:63,741,119–63,742,935 | 191.4 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:63,773,179–63,774,727 | 223.3 kb | Distal (>10kb) Multiome | 1169 | |
| chr17:63,826,794–63,828,024 | 276.9 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:63,841,547–63,843,442 | 292.4 kb | Distal (>10kb) Multiome | 1203 | |
| chr17:63,848,836–63,849,566 | 298.7 kb | Distal (>10kb) Multiome | 658 |
Genomic view of the DCAF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.