This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for DCAF17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:170,973,304–170,974,525 | 460.6 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr2:171,159,743–171,161,450 | 273.3 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr2:171,260,495–171,261,286 | 173.4 kb | Distal (>10kb) Multiome | 332 | |
| chr2:171,316,174–171,316,627 | 117.8 kb | Distal (>10kb) Multiome | 85 | |
| chr2:171,433,096–171,434,895 | 70 bp | At TSS Multiome | 1119 | |
| chr2:171,522,038–171,523,908 | 88.4 kb | Distal (>10kb) Multiome | 755 | |
| chr2:171,687,283–171,688,178 | 253.4 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the DCAF17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.