DCAF15

DDB1 and CUL4 associated factor 15 | MGC99481, C19orf72

Enables small molecule binding activity. Involved in protein polyubiquitination and regulation of natural killer cell activation. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-6

Biological processes 9 terms

Cul4-RING E3 ubiquitin ligase complex (GO:0080008)Cul4-RING E3 ubiquitin ligase complex (GO:0080008)protein binding (GO:0005515)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)regulation of natural killer cell activation (GO:0032814)regulation of natural killer cell activation (GO:0032814)small molecule binding (GO:0036094)

Expression (TPM)

TFs regulating DCAF15 0 TFs

Transcription factors with Perturb-seq knockdown data for DCAF15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DCAF15

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:13,747,559–13,748,233	204.7 kb	Distal (>10kb) Multiome	785
chr19:13,774,293–13,775,050	178.0 kb	Distal (>10kb) Multiome	904
chr19:13,794,728–13,795,999	157.3 kb	Distal (>10kb) Multiome	763
chr19:13,817,290–13,818,525	134.5 kb	Distal (>10kb) Multiome	368
chr19:13,833,328–13,834,074	118.8 kb	Distal (>10kb) Multiome	638
chr19:13,841,592–13,843,282	109.6 kb	Distal (>10kb) Multiome	600
chr19:13,846,368–13,848,126	104.8 kb	Distal (>10kb) Multiome	1040
chr19:13,850,226–13,850,701	102.0 kb	Distal (>10kb) Multiome	516
chr19:13,861,855–13,862,533	90.2 kb	Distal (>10kb) Multiome	655
chr19:13,872,706–13,873,325	79.5 kb	Distal (>10kb) Multiome	254
chr19:13,879,942–13,880,779	72.2 kb	Distal (>10kb) Multiome	780
chr19:13,905,895–13,906,734	46.3 kb	Distal (>10kb) Multiome	835
chr19:13,951,898–13,953,117	143 bp	At TSS Multiome	667
chr19:13,962,408–13,964,055	11.2 kb	Distal (>10kb) Multiome	166
chr19:13,978,193–13,979,385	26.1 kb	Distal (>10kb) Multiome	238
chr19:14,005,474–14,007,363	54.0 kb	Distal (>10kb) Multiome	1098
chr19:14,031,574–14,032,483	79.7 kb	Distal (>10kb) Multiome	726
chr19:14,057,383–14,057,841	105.2 kb	Distal (>10kb) Multiome	244
chr19:14,071,936–14,072,417	119.8 kb	Distal (>10kb) Multiome	676
chr19:14,072,991–14,073,911	121.1 kb	Distal (>10kb) Multiome	589
chr19:14,081,022–14,082,024	129.0 kb	Distal (>10kb) Multiome	806
chr19:14,089,535–14,092,049	138.5 kb	Distal (>10kb) Multiome	766
chr19:14,117,519–14,118,617	165.5 kb	Distal (>10kb) Multiome	734
chr19:14,136,079–14,137,770	184.4 kb	Distal (>10kb) Multiome	978
chr19:14,206,623–14,207,699	254.7 kb	Distal (>10kb) Multiome	444
chr19:14,247,378–14,248,008	295.1 kb	Distal (>10kb) Multiome	109
chr19:14,248,166–14,249,635	296.3 kb	Distal (>10kb) Multiome	230

Genome Browser

Genomic view of the DCAF15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.