The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for DBR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DBR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DBR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,009,757–138,010,666 | 164.8 kb | Distal (>10kb) Multiome | 133 | |
| chr3:138,019,195–138,020,432 | 154.9 kb | Distal (>10kb) Multiome | 203 | |
| chr3:138,115,002–138,116,017 | 59.5 kb | Distal (>10kb) Multiome | 555 | |
| chr3:138,118,769–138,119,220 | 55.8 kb | Distal (>10kb) Multiome | 232 | |
| chr3:138,174,233–138,175,030 | 88 bp | At TSS Multiome | 817 | |
| chr3:138,186,777–138,188,242 | 12.5 kb | Distal (>10kb) Multiome | 867 | |
| chr3:138,329,184–138,330,233 | 155.0 kb | Distal (>10kb) Multiome | 580 | |
| chr3:138,347,955–138,349,547 | 173.6 kb | Distal (>10kb) Multiome | 615 | |
| chr3:138,417,585–138,418,044 | 242.9 kb | Distal (>10kb) Multiome | 243 | |
| chr3:138,434,084–138,435,298 | 259.7 kb | Distal (>10kb) Multiome | 811 |
Genomic view of the DBR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.