This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for DBF4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DBF4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DBF4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,502,912–44,504,091 | 205.1 kb | Distal (>10kb) Multiome | 999 | |
| chr17:44,539,724–44,540,529 | 168.5 kb | Distal (>10kb) Multiome HiCAR | 135 | |
| chr17:44,543,007–44,544,301 | 165.4 kb | Distal (>10kb) Multiome HiCAR | 384 | |
| chr17:44,556,129–44,558,277 | 151.4 kb | Distal (>10kb) Multiome | 696 | |
| chr17:44,608,340–44,608,975 | 100.1 kb | Distal (>10kb) Multiome | 208 | |
| chr17:44,628,394–44,629,188 | 80.0 kb | Distal (>10kb) Multiome | 285 | |
| chr17:44,656,036–44,656,706 | 52.3 kb | Distal (>10kb) Multiome | 280 | |
| chr17:44,689,325–44,690,416 | 18.8 kb | Distal (>10kb) Multiome | 916 | |
| chr17:44,708,498–44,709,119 | at TSS | At TSS | 832 | |
| chr17:44,758,700–44,759,204 | 50.2 kb | Distal (>10kb) Multiome | 167 | |
| chr17:44,774,509–44,776,365 | 66.1 kb | Distal (>10kb) Multiome | 794 | |
| chr17:44,778,982–44,779,764 | 70.7 kb | Distal (>10kb) Multiome | 595 | |
| chr17:44,829,525–44,830,482 | 121.5 kb | Distal (>10kb) Multiome | 503 | |
| chr17:44,899,009–44,900,053 | 191.0 kb | Distal (>10kb) Multiome | 987 | |
| chr17:44,911,165–44,911,786 | 202.8 kb | Distal (>10kb) Multiome | 412 | |
| chr17:44,947,322–44,948,161 | 239.2 kb | Distal (>10kb) Multiome | 891 | |
| chr17:44,966,864–44,969,160 | 259.8 kb | Distal (>10kb) Multiome | 526 | |
| chr17:44,987,181–44,987,616 | 278.9 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the DBF4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.