The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for DARS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DARS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DARS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:173,669,068–173,669,991 | 154.9 kb | Distal (>10kb) Multiome | 247 | |
| chr1:173,714,634–173,715,651 | 109.6 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:173,824,030–173,825,369 | 70 bp | At TSS Multiome | 904 | |
| chr1:173,852,512–173,853,711 | 28.4 kb | Distal (>10kb) Multiome | 358 | |
| chr1:173,859,027–173,863,516 | 38.0 kb | Distal (>10kb) Multiome | 578 | |
| chr1:173,866,947–173,869,294 | 43.8 kb | Distal (>10kb) Multiome | 1182 | |
| chr1:174,021,545–174,024,235 | 197.7 kb | Distal (>10kb) Multiome | 1001 |
Genomic view of the DARS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.