The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for DACT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DACT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DACT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:58,627,887–58,628,118 | 9.8 kb | Proximal (<10kb) | 20 | |
| chr14:58,628,479–58,628,680 | 9.3 kb | Proximal (<10kb) | 63 | |
| chr14:58,629,413–58,629,727 | 8.2 kb | Proximal (<10kb) | 19 | |
| chr14:58,631,673–58,632,255 | 5.7 kb | Proximal (<10kb) | 177 | |
| chr14:58,633,913–58,634,116 | 3.8 kb | Proximal (<10kb) | 22 | |
| chr14:58,635,092–58,635,402 | 2.6 kb | Proximal (<10kb) | 69 | |
| chr14:58,637,252–58,639,111 | at TSS | At TSS | 493 | |
| chr14:58,640,040–58,640,195 | 2.1 kb | Proximal (<10kb) | 143 |
Genomic view of the DACT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.