CYP51A1

cytochrome P450 family 51 subfamily A member 1 | CP51, CYPL1, LDM, P450-14DM, P450L1, CYP51

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Developmental clusters: GC1

Biological processes 24 terms

cholesterol biosynthetic process (GO:0006695)cholesterol biosynthetic process (GO:0006695)cholesterol biosynthetic process via 24,25-dihydrolanosterol (GO:0033488)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)heme binding (GO:0020037)heme binding (GO:0020037)iron ion binding (GO:0005506)membrane (GO:0016020)monooxygenase activity (GO:0004497)negative regulation of amyloid-beta clearance (GO:1900222)negative regulation of amyloid-beta clearance (GO:1900222)negative regulation of protein catabolic process (GO:0042177)negative regulation of protein catabolic process (GO:0042177)negative regulation of protein secretion (GO:0050709)negative regulation of protein secretion (GO:0050709)oxidoreductase activity (GO:0016491)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)steroid biosynthetic process (GO:0006694)sterol 14-demethylase activity (GO:0008398)sterol 14-demethylase activity (GO:0008398)sterol 14-demethylase activity (GO:0008398)sterol metabolic process (GO:0016125)

Expression (TPM)

TFs regulating CYP51A1 0 TFs

Transcription factors with Perturb-seq knockdown data for CYP51A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYP51A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CYP51A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYP51A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:91,880,240–91,881,210	253.7 kb	Distal (>10kb) Multiome	902
chr7:91,940,112–91,941,746	193.6 kb	Distal (>10kb) Multiome	932
chr7:92,133,257–92,135,349	717 bp	At TSS Multiome	1155
chr7:92,178,862–92,179,934	44.6 kb	Distal (>10kb) Multiome	612
chr7:92,245,288–92,246,980	111.6 kb	Distal (>10kb) Multiome	964
chr7:92,424,381–92,424,856	290.1 kb	Distal (>10kb) Multiome	634
chr7:92,447,026–92,448,601	313.0 kb	Distal (>10kb) Multiome HiCAR	973

Genome Browser

Genomic view of the CYP51A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.