This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYP27C1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYP27C1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYP27C1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:126,942,302–126,943,261 | 277.6 kb | Distal (>10kb) Multiome | 184 | |
| chr2:126,971,341–126,972,649 | 248.2 kb | Distal (>10kb) Multiome | 617 | |
| chr2:127,024,615–127,026,056 | 194.7 kb | Distal (>10kb) Multiome | 462 | |
| chr2:127,049,850–127,050,796 | 170.0 kb | Distal (>10kb) Multiome | 428 | |
| chr2:127,105,209–127,108,284 | 113.0 kb | Distal (>10kb) Multiome | 594 | |
| chr2:127,218,704–127,220,652 | 314 bp | At TSS Multiome | 316 | |
| chr2:127,220,782–127,221,137 | 483 bp | At TSS | 102 | |
| chr2:127,293,716–127,294,914 | 73.9 kb | Distal (>10kb) Multiome | 876 | |
| chr2:127,386,971–127,388,844 | 167.1 kb | Distal (>10kb) Multiome | 986 | |
| chr2:127,407,631–127,408,983 | 187.9 kb | Distal (>10kb) Multiome | 878 | |
| chr2:127,415,703–127,416,595 | 195.8 kb | Distal (>10kb) Multiome | 501 | |
| chr2:127,422,503–127,423,812 | 203.0 kb | Distal (>10kb) Multiome | 321 | |
| chr2:127,463,310–127,464,007 | 243.4 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the CYP27C1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.