This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for CYCS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYCS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYCS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:24,910,037–24,911,071 | 214.5 kb | Distal (>10kb) Multiome | 134 | |
| chr7:24,971,370–24,972,325 | 153.5 kb | Distal (>10kb) Multiome | 393 | |
| chr7:24,978,754–24,981,093 | 145.0 kb | Distal (>10kb) Multiome | 889 | |
| chr7:25,124,560–25,125,967 | 183 bp | At TSS Multiome | 1019 | |
| chr7:25,179,707–25,180,806 | 55.0 kb | Distal (>10kb) Multiome | 607 | |
| chr7:25,243,706–25,244,747 | 119.0 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the CYCS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.