This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYBRD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYBRD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYBRD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:170,973,304–170,974,525 | 548.6 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr2:171,316,174–171,316,627 | 205.8 kb | Distal (>10kb) Multiome | 85 | |
| chr2:171,433,096–171,434,895 | 88.1 kb | Distal (>10kb) Multiome | 1119 | |
| chr2:171,513,734–171,514,152 | 8.1 kb | Proximal (<10kb) | 202 | |
| chr2:171,522,038–171,523,908 | 1.3 kb | Proximal (<10kb) Multiome | 755 | |
| chr2:171,524,078–171,524,224 | 1.8 kb | Proximal (<10kb) | 105 | |
| chr2:171,687,283–171,688,178 | 165.3 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the CYBRD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.