Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be involved in bicarbonate transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYB5RL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYB5RL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYB5RL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,944,886–53,946,958 | 254.0 kb | Distal (>10kb) Multiome | 806 | |
| chr1:53,956,851–53,957,534 | 242.8 kb | Distal (>10kb) Multiome | 255 | |
| chr1:54,052,651–54,054,132 | 146.6 kb | Distal (>10kb) Multiome | 833 | |
| chr1:54,121,133–54,122,207 | 78.4 kb | Distal (>10kb) Multiome | 490 | |
| chr1:54,199,512–54,200,664 | 92 bp | At TSS Multiome | 741 | |
| chr1:54,405,024–54,410,267 | 209.5 kb | Distal (>10kb) Multiome | 991 | |
| chr1:54,411,735–54,412,248 | 211.9 kb | Distal (>10kb) Multiome | 104 | |
| chr1:54,474,500–54,475,180 | 274.9 kb | Distal (>10kb) Multiome | 231 | |
| chr1:54,487,606–54,488,753 | 288.3 kb | Distal (>10kb) Multiome | 766 | |
| chr1:54,488,856–54,491,244 | 289.5 kb | Distal (>10kb) Multiome | 749 |
Genomic view of the CYB5RL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.