The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for CYB5R2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYB5R2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYB5R2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:7,507,737–7,508,506 | 166.3 kb | Distal (>10kb) Multiome | 150 | |
| chr11:7,512,733–7,514,729 | 160.5 kb | Distal (>10kb) Multiome | 725 | |
| chr11:7,571,498–7,572,368 | 102.4 kb | Distal (>10kb) Multiome HiCAR | 461 | |
| chr11:7,573,550–7,574,414 | 100.3 kb | Distal (>10kb) Multiome HiCAR | 486 | |
| chr11:7,665,631–7,666,054 | 7.4 kb | Proximal (<10kb) | 342 | |
| chr11:7,672,897–7,674,787 | 679 bp | At TSS Multiome | 379 | |
| chr11:7,905,555–7,906,470 | 231.9 kb | Distal (>10kb) Multiome | 98 | |
| chr11:7,909,636–7,910,173 | 235.6 kb | Distal (>10kb) Multiome | 37 |
Genomic view of the CYB5R2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.