Predicted to enable metal ion binding activity. Predicted to be involved in cilium movement and regulation of cilium beat frequency. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYB5D1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYB5D1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYB5D1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,560,249–7,562,536 | 295.8 kb | Distal (>10kb) Multiome | 759 | |
| chr17:7,572,039–7,574,418 | 285.1 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:7,579,018–7,579,876 | 278.3 kb | Distal (>10kb) Multiome | 844 | |
| chr17:7,583,063–7,584,547 | 274.0 kb | Distal (>10kb) Multiome | 921 | |
| chr17:7,588,871–7,590,534 | 267.5 kb | Distal (>10kb) Multiome | 319 | |
| chr17:7,614,065–7,615,780 | 242.6 kb | Distal (>10kb) Multiome | 708 | |
| chr17:7,627,090–7,628,247 | 229.9 kb | Distal (>10kb) Multiome | 712 | |
| chr17:7,650,010–7,652,127 | 207.0 kb | Distal (>10kb) Multiome | 467 | |
| chr17:7,685,876–7,686,907 | 171.5 kb | Distal (>10kb) Multiome | 765 | |
| chr17:7,687,214–7,687,777 | 170.2 kb | Distal (>10kb) Multiome | 710 | |
| chr17:7,687,867–7,688,863 | 169.4 kb | Distal (>10kb) Multiome | 700 | |
| chr17:7,703,383–7,703,975 | 154.1 kb | Distal (>10kb) Multiome | 141 | |
| chr17:7,704,799–7,705,590 | 152.6 kb | Distal (>10kb) Multiome | 325 | |
| chr17:7,716,832–7,717,983 | 140.4 kb | Distal (>10kb) Multiome | 759 | |
| chr17:7,833,417–7,837,960 | 20.7 kb | Distal (>10kb) Multiome | 1160 | |
| chr17:7,841,438–7,843,228 | 15.5 kb | Distal (>10kb) Multiome | 861 | |
| chr17:7,843,355–7,844,130 | 14.1 kb | Distal (>10kb) Multiome | 614 | |
| chr17:7,844,349–7,845,186 | 12.8 kb | Distal (>10kb) Multiome | 617 | |
| chr17:7,851,538–7,852,239 | 5.9 kb | Proximal (<10kb) Multiome | 531 | |
| chr17:7,853,062–7,853,638 | 4.1 kb | Proximal (<10kb) | 99 | |
| chr17:7,854,798–7,855,188 | 2.6 kb | Proximal (<10kb) | 106 | |
| chr17:7,856,600–7,858,747 | 231 bp | At TSS Multiome | 942 | |
| chr17:7,887,616–7,888,198 | 30.1 kb | Distal (>10kb) Multiome | 581 | |
| chr17:7,915,430–7,916,499 | 58.2 kb | Distal (>10kb) Multiome | 869 | |
| chr17:7,922,863–7,923,421 | 65.3 kb | Distal (>10kb) Multiome | 205 | |
| chr17:7,929,559–7,930,172 | 72.1 kb | Distal (>10kb) Multiome | 106 | |
| chr17:7,931,533–7,932,876 | 74.4 kb | Distal (>10kb) Multiome | 767 | |
| chr17:7,989,908–7,990,676 | 132.5 kb | Distal (>10kb) Multiome | 652 | |
| chr17:8,015,966–8,016,968 | 159.0 kb | Distal (>10kb) Multiome | 339 | |
| chr17:8,079,261–8,080,640 | 222.4 kb | Distal (>10kb) Multiome | 613 | |
| chr17:8,109,567–8,110,530 | 252.6 kb | Distal (>10kb) Multiome | 360 | |
| chr17:8,117,780–8,119,396 | 261.2 kb | Distal (>10kb) Multiome | 684 | |
| chr17:8,119,590–8,122,560 | 262.9 kb | Distal (>10kb) Multiome | 968 | |
| chr17:8,123,407–8,124,386 | 266.4 kb | Distal (>10kb) Multiome | 296 | |
| chr17:8,125,308–8,126,995 | 268.0 kb | Distal (>10kb) Multiome | 724 | |
| chr17:8,138,425–8,139,804 | 281.3 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,151,914–8,152,786 | 294.8 kb | Distal (>10kb) Multiome | 633 | |
| chr17:8,153,878–8,154,864 | 296.6 kb | Distal (>10kb) Multiome | 644 | |
| chr17:8,155,928–8,157,418 | 298.9 kb | Distal (>10kb) Multiome | 789 |
Genomic view of the CYB5D1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.