Predicted to enable transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis. Predicted to be located in chromaffin granule membrane. Predicted to be active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYB561. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYB561 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYB561, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,445,554–63,447,581 | 31 bp | At TSS Multiome | 896 | |
| chr17:63,476,359–63,478,095 | 31.1 kb | Distal (>10kb) Multiome | 520 | |
| chr17:63,478,783–63,479,370 | 32.9 kb | Distal (>10kb) Multiome | 419 | |
| chr17:63,522,589–63,523,803 | 77.0 kb | Distal (>10kb) Multiome | 705 | |
| chr17:63,549,660–63,551,443 | 104.1 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:63,600,715–63,601,423 | 154.7 kb | Distal (>10kb) Multiome HiCAR | 1122 | |
| chr17:63,621,512–63,623,359 | 175.9 kb | Distal (>10kb) Multiome | 956 | |
| chr17:63,698,705–63,701,428 | 254.0 kb | Distal (>10kb) Multiome HiCAR | 663 | |
| chr17:63,741,119–63,742,935 | 295.7 kb | Distal (>10kb) Multiome | 1057 |
Genomic view of the CYB561 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.