This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CUL4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUL4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUL4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:120,309,330–120,309,857 | 265.8 kb | Distal (>10kb) Multiome | 479 | |
| chrX:120,468,789–120,469,502 | 106.3 kb | Distal (>10kb) Multiome | 589 | |
| chrX:120,485,807–120,486,482 | 89.4 kb | Distal (>10kb) Multiome | 698 | |
| chrX:120,560,301–120,561,794 | 14.4 kb | Distal (>10kb) Multiome | 727 | |
| chrX:120,569,807–120,570,337 | 8.4 kb | Proximal (<10kb) | 33 | |
| chrX:120,603,687–120,604,407 | 28.5 kb | Distal (>10kb) Multiome HiCAR | 581 | |
| chrX:120,629,690–120,630,593 | 54.6 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the CUL4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.