Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CUL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:34,802,414–34,803,257 | 287.7 kb | Distal (>10kb) Multiome | 156 | |
| chr10:34,808,483–34,809,768 | 281.4 kb | Distal (>10kb) Multiome | 231 | |
| chr10:34,813,705–34,816,058 | 275.1 kb | Distal (>10kb) Multiome | 650 | |
| chr10:35,089,654–35,090,939 | 138 bp | At TSS Multiome | 797 | |
| chr10:35,126,359–35,127,943 | 36.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr10:35,335,922–35,337,633 | 245.9 kb | Distal (>10kb) Multiome | 701 | |
| chr10:35,384,192–35,385,102 | 294.0 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the CUL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.