Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CUBN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUBN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUBN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:16,765,187–16,766,242 | 101.1 kb | Distal (>10kb) Multiome | 148 | |
| chr10:16,816,770–16,818,262 | 49.3 kb | Distal (>10kb) Multiome | 801 | |
| chr10:16,891,324–16,892,326 | 24.8 kb | Distal (>10kb) Multiome | 599 | |
| chr10:16,962,424–16,962,891 | 95.8 kb | Distal (>10kb) Multiome | 31 | |
| chr10:17,120,753–17,120,977 | 8.8 kb | Proximal (<10kb) | 36 | |
| chr10:17,200,899–17,202,136 | 334.7 kb | Distal (>10kb) Multiome HiCAR | 1040 | |
| chr10:17,228,175–17,230,908 | 362.2 kb | Distal (>10kb) Multiome HiCAR | 920 | |
| chr10:17,379,036–17,380,059 | 512.6 kb | Distal (>10kb) Multiome HiCAR | 120 |
Genomic view of the CUBN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.