The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for CTSV. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTSV upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTSV, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:96,777,772–96,778,352 | 261.1 kb | Distal (>10kb) Multiome | 632 | |
| chr9:96,854,007–96,854,748 | 184.6 kb | Distal (>10kb) Multiome | 699 | |
| chr9:96,875,314–96,876,157 | 163.3 kb | Distal (>10kb) Multiome | 643 | |
| chr9:97,013,175–97,013,888 | 25.5 kb | Distal (>10kb) Multiome | 273 | |
| chr9:97,038,375–97,039,810 | 100 bp | At TSS Multiome | 639 | |
| chr9:97,046,118–97,046,579 | 7.0 kb | Proximal (<10kb) | 263 | |
| chr9:97,051,679–97,052,459 | 12.9 kb | Distal (>10kb) Multiome | 224 | |
| chr9:97,214,476–97,215,067 | 175.6 kb | Distal (>10kb) Multiome | 48 | |
| chr9:97,220,933–97,222,786 | 182.5 kb | Distal (>10kb) Multiome | 231 | |
| chr9:97,231,971–97,232,981 | 193.4 kb | Distal (>10kb) Multiome | 260 | |
| chr9:97,238,002–97,238,892 | 199.3 kb | Distal (>10kb) Multiome | 684 | |
| chr9:97,306,799–97,308,104 | 268.2 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the CTSV locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.