This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for CTDSP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTDSP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTDSP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,216,755–218,218,281 | 182.8 kb | Distal (>10kb) Multiome | 875 | |
| chr2:218,269,385–218,270,929 | 129.5 kb | Distal (>10kb) Multiome HiCAR | 913 | |
| chr2:218,290,037–218,290,611 | 109.6 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr2:218,291,910–218,292,722 | 107.4 kb | Distal (>10kb) Multiome HiCAR | 695 | |
| chr2:218,322,154–218,324,454 | 76.7 kb | Distal (>10kb) Multiome | 914 | |
| chr2:218,367,421–218,368,194 | 32.0 kb | Distal (>10kb) Multiome | 450 | |
| chr2:218,387,091–218,388,220 | 12.0 kb | Distal (>10kb) Multiome | 514 | |
| chr2:218,395,568–218,397,399 | 3.6 kb | Proximal (<10kb) Multiome | 1048 | |
| chr2:218,397,484–218,401,433 | 1.9 kb | Proximal (<10kb) Multiome | 1114 | |
| chr2:218,405,424–218,407,478 | 6.6 kb | Proximal (<10kb) Multiome | 1093 | |
| chr2:218,567,787–218,569,400 | 168.6 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:218,658,668–218,660,011 | 259.7 kb | Distal (>10kb) Multiome | 870 | |
| chr2:218,671,689–218,672,558 | 272.2 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the CTDSP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.