Transcription factors with Perturb-seq knockdown data for CSTF3-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSTF3-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSTF3-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:32,891,344–32,894,653 | 268.7 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:33,015,524–33,016,542 | 145.7 kb | Distal (>10kb) Multiome | 837 | |
| chr11:33,038,936–33,040,258 | 122.2 kb | Distal (>10kb) Multiome | 917 | |
| chr11:33,040,776–33,041,667 | 120.4 kb | Distal (>10kb) Multiome | 161 | |
| chr11:33,049,426–33,050,404 | 111.7 kb | Distal (>10kb) Multiome | 103 | |
| chr11:33,159,614–33,159,870 | 1.8 kb | Proximal (<10kb) | 92 | |
| chr11:33,160,986–33,162,028 | 106 bp | At TSS Multiome | 908 | |
| chr11:33,256,736–33,259,047 | 96.9 kb | Distal (>10kb) Multiome | 993 | |
| chr11:33,375,703–33,377,039 | 214.7 kb | Distal (>10kb) Multiome | 329 |
Genomic view of the CSTF3-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.