The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CSRNP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSRNP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSRNP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:50,842,736–50,843,181 | 240.1 kb | Distal (>10kb) Multiome | 133 | |
| chr12:51,025,646–51,026,823 | 56.7 kb | Distal (>10kb) Multiome | 1016 | |
| chr12:51,047,625–51,048,573 | 35.0 kb | Distal (>10kb) Multiome | 892 | |
| chr12:51,082,637–51,083,972 | 462 bp | At TSS Multiome | 937 | |
| chr12:51,172,263–51,173,510 | 89.9 kb | Distal (>10kb) Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 135.0 kb | Distal (>10kb) Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 155.8 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 186.9 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 237.8 kb | Distal (>10kb) Multiome | 315 | |
| chr12:51,371,336–51,371,863 | 288.5 kb | Distal (>10kb) Multiome | 431 |
Genomic view of the CSRNP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.