This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for CSNK1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSNK1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSNK1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,976,595–81,978,312 | 295.8 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 253.3 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 250.4 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 241.5 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 235.9 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 221.7 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 207.6 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 174.9 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 169.9 kb | Distal (>10kb) Multiome | 672 | |
| chr17:82,212,405–82,213,592 | 60.6 kb | Distal (>10kb) Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 44.5 kb | Distal (>10kb) Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 217 bp | At TSS Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 5.4 kb | Proximal (<10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 19.4 kb | Distal (>10kb) Multiome | 944 | |
| chr17:82,414,581–82,415,044 | 141.4 kb | Distal (>10kb) Multiome | 799 | |
| chr17:82,417,993–82,419,018 | 145.0 kb | Distal (>10kb) Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 177.3 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 185.1 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 221.2 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 223.9 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 246.1 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the CSNK1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.