Predicted to be involved in regulation of dendrite development. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CSMD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSMD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSMD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:111,805,064–111,806,327 | 1631.4 kb | Distal (>10kb) Multiome HiCAR | 187 | |
| chr8:111,981,532–111,982,527 | 1455.0 kb | Distal (>10kb) Multiome HiCAR | 128 | |
| chr8:112,772,170–112,773,182 | 664.2 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr8:112,808,221–112,810,152 | 626.9 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr8:113,432,064–113,435,349 | 1.5 kb | Proximal (<10kb) | 439 | |
| chr8:113,435,470–113,437,300 | at TSS | At TSS | 94 | |
| chr8:113,437,553–113,439,048 | 670 bp | At TSS | 396 |
Genomic view of the CSMD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.