The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CRYL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRYL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRYL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,414,810–20,415,479 | 110.7 kb | Distal (>10kb) Multiome | 89 | |
| chr13:20,525,162–20,526,319 | at TSS | At TSS | 695 | |
| chr13:20,566,412–20,567,667 | 41.2 kb | Distal (>10kb) Multiome | 901 | |
| chr13:20,703,037–20,704,890 | 178.4 kb | Distal (>10kb) Multiome | 620 | |
| chr13:20,773,202–20,774,439 | 248.0 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the CRYL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.