Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CRYBG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRYBG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRYBG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:106,085,814–106,086,566 | 274.4 kb | Distal (>10kb) Multiome | 502 | |
| chr6:106,325,124–106,326,565 | 35.1 kb | Distal (>10kb) Multiome | 957 | |
| chr6:106,360,205–106,361,449 | 94 bp | At TSS Multiome | 616 | |
| chr6:106,511,736–106,513,208 | 151.9 kb | Distal (>10kb) Multiome | 661 | |
| chr6:106,629,212–106,630,045 | 268.8 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the CRYBG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.