Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CRHBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRHBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRHBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,715,026–76,716,740 | 237.3 kb | Distal (>10kb) Multiome | 666 | |
| chr5:76,789,270–76,790,249 | 163.5 kb | Distal (>10kb) Multiome | 123 | |
| chr5:76,818,476–76,819,940 | 134.5 kb | Distal (>10kb) Multiome | 686 | |
| chr5:76,873,943–76,874,791 | 79.0 kb | Distal (>10kb) Multiome HiCAR | 261 | |
| chr5:76,953,306–76,954,445 | 354 bp | At TSS Multiome | 235 | |
| chr5:76,956,086–76,956,328 | 2.7 kb | Proximal (<10kb) | 12 | |
| chr5:77,030,193–77,031,058 | 77.0 kb | Distal (>10kb) Multiome | 903 | |
| chr5:77,076,843–77,078,059 | 124.2 kb | Distal (>10kb) Multiome | 396 | |
| chr5:77,086,556–77,087,540 | 133.5 kb | Distal (>10kb) Multiome | 768 | |
| chr5:77,231,266–77,232,033 | 278.3 kb | Distal (>10kb) Multiome | 69 |
Genomic view of the CRHBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.