CPT1C
carnitine palmitoyltransferase 1C | CATL1, CPT1P, CPTIC, FLJ23809

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Biological processes 26 terms
AMPA glutamate receptor complex (GO:0032281)acyltransferase activity (GO:0016746)axon (GO:0030424)axon (GO:0030424)carnitine O-palmitoyltransferase activity (GO:0004095)carnitine metabolic process (GO:0009437)carnitine metabolic process (GO:0009437)catalytic activity (GO:0003824)dendrite (GO:0030425)dendrite (GO:0030425)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)fatty acid metabolic process (GO:0006631)fatty acid metabolic process (GO:0006631)glutamatergic synapse (GO:0098978)macromolecule depalmitoylation (GO:0098734)mitochondrion (GO:0005739)palmitoyl-(protein) hydrolase activity (GO:0008474)palmitoyl-(protein) hydrolase activity (GO:0008474)postsynapse (GO:0098794)protein binding (GO:0005515)regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)
Expression (TPM)
CPT1C — as a Regulated Gene

TFs regulating CPT1C 0 TFs

Transcription factors with Perturb-seq knockdown data for CPT1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPT1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CPT1C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPT1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:49,403,611–49,404,247 287.2 kb Distal (>10kb) Multiome 305
chr19:49,432,343–49,432,785 258.6 kb Distal (>10kb) Multiome 103
chr19:49,436,149–49,436,821 254.6 kb Distal (>10kb) Multiome 248
chr19:49,441,067–49,441,861 249.6 kb Distal (>10kb) Multiome 223
chr19:49,442,072–49,444,054 248.2 kb Distal (>10kb) Multiome 914
chr19:49,451,347–49,452,239 239.3 kb Distal (>10kb) Multiome 764
chr19:49,452,723–49,453,850 237.8 kb Distal (>10kb) Multiome 847
chr19:49,476,063–49,476,551 214.7 kb Distal (>10kb) Multiome 244
chr19:49,487,027–49,488,279 203.7 kb Distal (>10kb) Multiome 964
chr19:49,495,613–49,496,661 194.9 kb Distal (>10kb) Multiome 919
chr19:49,500,403–49,501,353 190.4 kb Distal (>10kb) Multiome 405
chr19:49,512,565–49,513,700 178.1 kb Distal (>10kb) Multiome 655
chr19:49,527,651–49,528,221 163.2 kb Distal (>10kb) Multiome 354
chr19:49,533,232–49,534,476 157.1 kb Distal (>10kb) Multiome 534
chr19:49,555,629–49,557,180 135.0 kb Distal (>10kb) Multiome 294
chr19:49,580,125–49,580,813 110.5 kb Distal (>10kb) Multiome 848
chr19:49,589,601–49,594,008 97.6 kb Distal (>10kb) Multiome 994
chr19:49,638,063–49,638,728 52.8 kb Distal (>10kb) Multiome 237
chr19:49,639,671–49,642,787 50.7 kb Distal (>10kb) Multiome 1067
chr19:49,664,165–49,665,096 26.6 kb Distal (>10kb) Multiome 679
chr19:49,665,345–49,666,430 25.2 kb Distal (>10kb) Multiome 721
chr19:49,672,105–49,672,787 18.7 kb Distal (>10kb) Multiome 625
chr19:49,676,058–49,678,754 14.2 kb Distal (>10kb) Multiome 1033
chr19:49,680,433–49,681,147 10.4 kb Distal (>10kb) Multiome 435
chr19:49,689,499–49,690,214 920 bp At TSS 247
chr19:49,690,485–49,691,761 17 bp At TSS Multiome 327
chr19:49,746,188–49,746,748 55.3 kb Distal (>10kb) Multiome 283
chr19:49,766,231–49,767,440 75.6 kb Distal (>10kb) Multiome 718
chr19:49,802,146–49,802,787 111.4 kb Distal (>10kb) Multiome 200
chr19:49,805,226–49,805,871 114.4 kb Distal (>10kb) Multiome 245
chr19:49,808,201–49,809,746 117.8 kb Distal (>10kb) Multiome 509
chr19:49,812,926–49,813,834 122.3 kb Distal (>10kb) Multiome 650
chr19:49,817,356–49,818,721 127.1 kb Distal (>10kb) Multiome 784
chr19:49,850,394–49,852,067 159.8 kb Distal (>10kb) Multiome 862
chr19:49,866,817–49,868,124 176.3 kb Distal (>10kb) Multiome 874
chr19:49,869,068–49,870,398 178.5 kb Distal (>10kb) Multiome 832
chr19:49,875,842–49,878,576 186.6 kb Distal (>10kb) Multiome 1153
chr19:49,889,853–49,891,381 199.4 kb Distal (>10kb) Multiome 640
chr19:49,928,884–49,930,473 238.8 kb Distal (>10kb) Multiome 1141
chr19:49,987,157–49,987,669 296.2 kb Distal (>10kb) Multiome 1095

Genome Browser

Genomic view of the CPT1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:49,393,611 – 49,997,669
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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